What is Cosmoderm®? CosmoDerm and CosmoPlast Human-Based Collagen implants are sterile injectable liquids made of highly purified human collagen, a natural protein that supports the skin. Cosmoderm or CosmoPlast is injected into the skin to correct soft tissue defects such as wrinkles and acne scars. These products also contain lidocaine, which numbs the skin at the site of injection. CosmoDerm is used for minor skin defects. CosmoPlast is used for more serious defects. When is Cosmoderm® used? Cosmoderm® is used to correct soft tissue contour defects, such as wrinkles and acne scars. What will Cosmoderm® accomplish? Previous studies with injections of collagen derived from cows showed that collagen injections can fill soft tissue contour defects. Clinical studies of injections with human collagen showed that the frequency of adverse immune responses (rejection by the body) with the use of CosmoDerm™ 1 Human-Based Collagen is less than 1.3%. Because of the low percent of adverse responses, each of these two products may be injected without a skin test prior to treatment. When should Cosmoderm® not be used? * In patients with severe or multiple allergies that have led to anaphylactic shock, an acute reaction that requires immediate emergency medical assistance. * In patients with known allergy to lidocaine. * In patients with an inflamed or infected skin condition. * For increasing breast size. * For implanting into bone, tendon, ligament, or muscle.